Bryan Johnson, the tech entrepreneur and founder of “Project Blueprint,” has redefined the pursuit of longevity and optimal health. Spending around $2 million annually on his health regimen, he incorporates cutting-edge supplements and protocols to maintain a youthful biological age. His approach, backed by scientific research and the expertise of over 30 specialists, includes 27 core supplements tailored to his unique needs. This guide delves into Johnson’s supplement regimen, offering insights for those looking to enhance their own health and wellness.
Understanding Bryan Johnson’s Approach to Supplementation
Bryan Johnson’s health plan is meticulously designed and based on scientific evidence. The cornerstone of his regimen is the “Blueprint Stack,” a comprehensive mix of over 100 supplements and nutrients crafted to address specific aspects of his health, including organ function, cognitive enhancement, and anti-aging.
Key aspects of Johnson’s routine include:
Daily Exercise: Approximately 4.5 hours of physical activity.
Dietary Precision: A highly curated diet that complements his supplements.
Supplement Focus Areas: Longevity, brain health, inflammation control, and energy optimization.
Core Components of Bryan Johnson’s Supplement List
Johnson’s supplement protocol focuses on three main areas:
Longevity and Anti-Aging: Supplements like rapamycin, resveratrol, and metformin aim to slow biological aging and improve cellular health.
Cognitive Enhancement: Nootropics such as nicotinamide riboside and phosphatidylserine support brain function and mental sharpness.
Essential Nutrients: Vitamins D3, magnesium, and omega-3 fatty acids provide foundational health benefits.
Key Supplements and Their Benefits
Supplement | Purpose |
---|---|
Nicotinamide Riboside | DNA repair and mitochondrial health |
Lithium | Neurological support |
Turmeric | Anti-inflammatory properties |
Resveratrol | Cellular health and anti-aging |
Metformin | Insulin sensitivity and longevity |

Fat-Soluble Vitamins
Johnson’s regimen includes:
Fat-Soluble Vitamins: Vitamins A, D, E, and K for immune function, skin health, and bone strength.
Water-Soluble Vitamins: Vitamin C and B-complex for energy, nerve health, and cardiovascular support.
These essential nutrients are timed strategically to optimize absorption and efficacy.
Longevity-Focused Supplements
Bryan Johnson’s commitment to longevity is evident in his use of supplements that support telomere health, reduce oxidative stress, and enhance cellular repair. Notable examples include:
Resveratrol: 500 mg daily for its anti-aging properties.
Metformin: 1.5 g daily to improve metabolic health.
Performance Enhancement Supplements
To maintain peak physical performance, Johnson incorporates:
Creatine: For muscle strength and endurance.
Beta-Alanine: To improve exercise capacity and reduce fatigue.
Timing and Dosage Strategies
Bryan Johnson’s supplement timing is as important as the supplements themselves. Key aspects include:
Morning routine: 20 supplements, including collagen peptides (12.5 g) and omega-3s (800 mg EPA/DHA/DPA).
Evening supplements: Melatonin (300 mcg) for improved sleep quality.
Gut health: Prebiotics such as GOS (1/2 tsp) and inulin (1 tsp).
Comprehensive Supplement Schedule
Upon Waking | With Dinner at 11 am | Before Bed | Other |
Acarbose 200 mg (Rx) | Acarbose 200 mg (Rx) | Melatonin 300 mcg | Extra Virgin Olive Oil, 30 mL daily |
Ashwagandha 600 mg | BroccoMax 17.5 mg | Pea Protein, 29 grams daily | |
Astaxanthin 12 mg | Ca-AKG 1 g | Dark Chocolate, 15 grams | |
B Complex (1/2 pill, twice a wk) | Cocoa Flavanols 500 mg | Rapamycin (Rx): | |
Boron 2 mg | Garlic 2.4 g equivalent | Week 1: 13 mg | |
BroccoMax 17.5 mg | Garlic 1.2 g (Kyolic) | Week 2: 9 mg | |
C 500 mg | Glucosamine Sulphate 2KCL 1,500 mg | Week 3: 13 mg | |
Ca-AKG 1 gram | Hyaluronic Acid 300 mg | Week 4: 9 mg | |
Cocoa Flavanols 500 mg | L-Lysine 1 g | ||
CoQ10 100 mg | L-Tyrosine 500 mg | 17α-E2, 8 mg weekly (transdermal) | |
D-3 2,000 IU | Metformin ER 500 mg (Rx) | B12 Methylcobalamin (1x weekly) | |
DHEA 25 mg | N-Acetyl-L-Cysteine (NAC) 1,800 mg | Aspirin 81 mg (3x weekly) | |
E 67 mg | NR 375 mg OR NMN 500 mg (6x weekly) | 112 mcg Levothyroxine | |
EPA/DHA/DPA 800 mg | Taurine 1 g | 60 mg Armour Thyroid (Rx) | |
Fisetin 200 mg | Turmeric 1 g | ||
Garlic 2.4 g equivalent | Viviscal (men/women) 1 pill | ||
Garlic 1.2 g (Kyolic) | |||
Genistein 125 mg | |||
Ginger Root 1.1 g | |||
Glucosamine Sulphate 2KCL 1,500 mg | |||
Iodine (Potassium Iodide) 125 mcg | |||
K2-MK4, 5 mg | |||
K1, 1.5 mg | |||
K2 MK-7 600 mcg | |||
Lithium 1 mg | |||
Lycopene 10 mg | |||
Lysine 1 g | |||
Metformin ER 1,500 mg (Rx) | |||
Nicotinamide Riboside 375 mg | |||
N-Acetyl-L-Cysteine (NAC) 1,800 mg | |||
Proferrin 10 mg | |||
Spermidine 10 mg | |||
Turmeric 1 g | |||
Taurine 2 g | |||
Viviscal (male/female) 1 pill | |||
Zeaxanthin (20 mg Lutein, 4 mg Zeaxanthin, 3x weekly) | |||
Zinc 15 mg |
Safety and Side Effects
Taking over 100 supplements daily requires careful monitoring. Potential risks include:
Digestive issues (e.g., from metformin or acarbose).
Interactions with medications.
Best Practices:
Consult a healthcare professional before starting any supplement regimen.
Monitor biomarkers regularly to assess the effectiveness and safety of the protocol.
Adjust dosages based on individual needs and health goals.

Cost Analysis and Practical Considerations
Johnson’s $2 million annual health investment includes supplements, diagnostics, and expert consultations. For most individuals, achieving similar results on a smaller budget requires:
Prioritizing high-impact supplements (e.g., omega-3s, vitamin D, resveratrol).
Comparing prices and opting for reputable brands.
Category | Estimated Monthly Cost |
Vitamins and Minerals | $100–$300 |
Nootropics | $50–$200 |
Longevity-Focused Supplements | $200–$500 |
Tracking and Measuring Effectiveness
Biomarker testing is central to Johnson’s regimen. Metrics such as inflammation levels, hormone balance, and biological age are regularly assessed to measure progress. Adopting a similar approach can help individuals refine their own supplement plans.
Final Thoughts on Bryan Johnson’s Supplement Philosophy
Bryan Johnson’s approach to health supplementation offers valuable insights into optimizing longevity, cognitive function, and overall well-being. While his regimen may not be feasible for everyone, the principles of scientific research, precision, and consistency are universally applicable. By tailoring a personalized protocol and consulting healthcare professionals, individuals can adopt elements of Johnson’s strategy to enhance their health outcomes.
FAQ
1. What is the scientific basis of Bryan Johnson's supplement regimen?
Bryan Johnson’s regimen is based on cutting-edge scientific research and developed in collaboration with over 30 health and longevity experts. Biomarker testing and evidence-based protocols ensure the effectiveness of his approach.
2. What are the key areas of focus in Bryan Johnson's supplement plan?
The plan targets three main areas: longevity and anti-aging, cognitive enhancement, and foundational health with essential vitamins and minerals.
3. What essential vitamins and minerals are included in Bryan Johnson's protocol?
His protocol features fat-soluble vitamins (A, D, E, K) for immunity and bone health and water-soluble vitamins (B-complex, C) for energy and nerve function. Minerals like magnesium and potassium are also critical for overall health.
4. Which nootropics are part of Bryan Johnson's supplement routine?
Key nootropics include nicotinamide riboside for DNA repair and phosphatidylserine for memory and focus. These supplements aim to boost brain health and cognitive performance.
5. What supplements does Bryan Johnson take for longevity?
Bryan Johnson includes resveratrol and metformin to support cellular health, telomere protection, and anti-aging processes. These supplements help him maintain a youthful biological age.
6. How are Bryan Johnson's supplements timed and dosed?
Supplements are carefully timed for maximum absorption and efficacy. Mornings include collagen peptides and omega-3s, while evenings feature melatonin and GABA for relaxation and sleep.
7. What are Bryan Johnson's performance enhancement supplements?
Creatine and beta-alanine are part of his protocol to enhance muscle strength, endurance, and physical performance.
8. Are there risks associated with Bryan Johnson's supplement regimen?
Potential side effects include digestive issues or interactions with other medications. Regular medical supervision and biomarker tracking are crucial to ensure safety.
9. How much does Bryan Johnson's supplement regimen cost?
His protocol is a significant investment, with supplements alone costing hundreds to thousands of dollars monthly. For budget-conscious individuals, focusing on high-impact supplements is recommended.
10. How does Bryan Johnson evaluate the effectiveness of his supplements?
He uses biomarker testing and performance metrics to assess the impact of his regimen, allowing for precise adjustments to optimize health outcomes.
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