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Home Nutrition

NMN vs NMNH: Uncover the Differences

by Sarah Bennett
December 28, 2024
Reading Time: 16 mins read
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NMN VS NMNH

By age 50, 90% of NAD+ levels are lost. This shows how crucial NAD+ precursors like NMN and NMNH are for our health. They help keep our cells working well and fight aging effects.

Studies show NMN can boost energy and insulin sensitivity in older mice. NMNH also raises NAD+ and NADH levels. Both are vital for our cells and metabolism.

The quest for healthy aging has led to NMN and NMNH. NMN is a common supplement, while NMNH might work faster. They improve energy, metabolism, and even heart health. Knowing their differences helps us choose the best NAD+ supplement for our cells.

Understanding NMN and NMNH Basics

NMN supplements are popular for boosting NAD+ levels, key for energy in cells. NMNH benefits are still being studied, but it quickly raises NAD+ levels. Knowing how NMN and NMNH work in our bodies is important.

Cellular energy keeps cells healthy, and NMN supplements help with this. They increase NAD+ levels, which can improve energy, repair cells, and overall health.

What is NMN (Nicotinamide Mononucleotide)?

NMN is a molecule that boosts NAD+ levels in our bodies. It’s found in foods like broccoli and avocado. But, NMN supplements give a bigger boost to NAD+ levels.

What is NMNH (Nicotinamide Mononucleotide Reduced Form)?

NMNH is NMN’s reduced form, known for quickly raising NAD+ levels. While NMN supplements are common, NMNH benefits are still being studied. Its potential uses are being explored.

The Role of NAD+ in Cellular Health

NAD+ is crucial for energy, repair, and healthy aging. By 50, most people have half the NAD+ they had in their 20s. This makes NAD+ boosters like NMN supplements appealing for keeping cells healthy.

NMN VS NMNH

Molecular Structure and Chemical Properties

The NMN structure and NMNH composition are key to understanding their roles. NMNH has an extra hydrogen molecule, making it different from NMN. This might make it more stable and effective in the body.

Research shows NMNH can boost NAD+ levels by 5 times more than NMN. It stays stable at pH 7.0 and room temperature for about 2.4 days. This is longer than NRH, showing NMNH could be better for cell health.

Key differences between NMN and NMNH include:

  • Stability: NMNH has a longer half-life than NMN
  • Effectiveness: NMNH can achieve higher NAD+ levels than NMN
  • Chemical properties: NMNH has an extra hydrogen molecule, making it chemically distinct from NMN

The NMN structure and NMNH composition are crucial for their NAD+ precursor chemistry. Knowing these differences helps in creating better supplements for cell health.

SupplementNAD+ IncreaseStability
NMN1-foldShort half-life
NMNH5-foldLong half-life

The Key Differences Between NMN vs NMNH

When we look at NMN vs NMNH, it’s key to see how they differ. NMNH boosts NAD+ levels by nearly 10 times more than NMN. This shows its strong ability to enhance NAD+ and get into cells.

Some main differences between NMN and NMNH are:

  • Stability: NMNH stays stable longer, which helps it last longer as a supplement.
  • Absorption rates: NMNH gets absorbed quickly, raising NAD+ levels in 15 minutes. NMN’s effects don’t last as long.
  • Bioavailability factors: NMNH turns into NAD+ more efficiently. This leads to higher NAD+ levels in cells and tissues.

These differences greatly affect how well NMN vs NMNH work for cell health and NAD+ boost. As research goes on, it’s important to think about these points when picking between NMN and NMNH supplements.

CompoundNAD+ EnhancementCellular Uptake
NMNEstablished benefitsWell-studied
NMNHPromising resultsFaster absorption

Research and Scientific Evidence

Recent studies have shown that NMN and NMNH can boost NAD+ levels. NMN trials have shown promise in heart health and brain function. For example, a study in Nature Communications found that NMN raised NAD+ in adults.

However, NMNH studies are still in their early stages. Most research is done in labs or on animals.

NAD+ research also looks at how NMN and NMNH affect metabolism and exercise. NMN has helped old mice last longer, but NR has hurt rat exercise performance. These results show we need more research to understand these compounds fully.

Some important findings from NMN trials include:

  • Improved cardiac function
  • Increased endurance
  • Enhanced cognitive function

On the other hand, NMNH studies focus on its benefits over NMN. They look at its stability and how well it’s absorbed. As research on NAD+ grows, it’s key to look at both NMN and NMNH studies. This helps figure out the best way to increase NAD+ levels.

Health Benefits and Applications

NMN and NMNH have many health benefits, including being anti-aging supplements. NMN boosts NAD+ levels in tissues quickly. NMNH also shows promise in improving energy and mitochondrial function.

Key benefits include:

  • Improved energy metabolism
  • Enhanced cellular repair mechanisms
  • Potential cognitive benefits, such as supporting brain function and slowing age-related cognitive decline
  • Cardiovascular benefits, including improved blood flow and arterial health
  • Metabolic health applications, including potential improvements in insulin sensitivity and weight management

Research shows NMNH is more bioavailable than NMN, making it better for NAD+ levels. It also increases NAD+ levels in a specific way. Plus, it stays stable in certain conditions.

A study showed NMNH boosts NAD+ levels by 5 times in HepG2 cells. NMN only slightly increases levels. This makes NMNH a better choice for boosting NAD+ levels. Both NMN and NMNH look promising as anti-aging supplements. More research is needed to understand their full benefits.

Safety Considerations and Side Effects

When thinking about NMN and NMNH supplements, it’s key to look at the risks and side effects. NMN has been studied a lot, and human trials show it’s safe up to 500 mg for 12 weeks. But, NMNH’s safety is not as clear, with fewer human trials.

Studies say NMN is usually safe, with few side effects. But, it’s important to stick to the right dosage to avoid risks. The usual dose for NMN supplements is 250 mg to 1,200 mg a day. Some studies show higher doses can help more with energy.

A summary of the key considerations for NMN and NMNH supplementation is as follows:

  • NMN is considered safe with minimal side effects at doses up to 1,200 mg daily.
  • NMNH’s safety profile is not as established, and caution is advised when considering its use.
  • The recommended NAD+ booster dosage for NMN supplements is between 250 mg to 1,200 mg per day.

In conclusion, while NMN and NMNH supplements might have health benefits, safety is key. Always follow the recommended dosage and talk to a healthcare professional. This way, you can enjoy the benefits of NAD+ boosters while staying safe.

SupplementSafety ProfileRecommended Dosage
NMNEstablished, minimal side effects250 mg to 1,200 mg per day
NMNHNot established, caution advisedNot recommended due to limited safety data

Conclusion

Our detailed comparison shows NMN (Nicotinamide Mononucleotide) is the top choice for NAD+ supplements. It has a lot of research backing it, is safe, and helps with energy, health, and aging. Many people choose it for these reasons.

Even though NMNH (Nicotinamide Mononucleotide Reduced Form) looks promising, it doesn’t have as much research or availability as NMN. But, as more studies come out, NMNH might become a good option too. For now, NMN is the best choice for NAD+ supplements.

When deciding between NMN and NMNH, think about your health goals, what research you’re comfortable with, and how much risk you’re willing to take. NMN is safer and more proven, but NMNH might offer faster benefits. It depends on what you’re looking for.

The world of NAD+ supplements is always changing. Keeping up with new research is key for those wanting to improve their health and live longer. By knowing the differences between NMN and NMNH, you can choose what’s best for you.

FAQ

What is NMN (Nicotinamide Mononucleotide)?

NMN is a molecule found naturally in our bodies. It helps make NAD+, which is key for energy, DNA repair, and health.

What is NMNH (Nicotinamide Mononucleotide Reduced Form)?

NMNH is a version of NMN with an extra hydrogen. It might be absorbed and turned into NAD+ faster than NMN.

What is the role of NAD+ in cellular health?
NAD+ is vital for energy, DNA repair, and cell signaling. It helps mitochondria work right and affects aging and lifespan.
How do the molecular structures of NMN and NMNH differ?

NMN and NMNH differ by one hydrogen molecule. This changes their chemical properties and effects on the body.

What are the key differences between NMN and NMNH in terms of stability, absorption, and bioavailability?

NMN and NMNH have different stability and absorption rates. NMNH might be more stable and absorbed faster, leading to quicker NAD+ conversion. But, their bioavailability is still being studied.

What is the current state of research on NMN and NMNH?

NMN has shown promise in clinical trials for metabolism, heart health, and brain function. NMNH research is early, but its unique traits are of interest.

What are the potential health benefits of NMN and NMNH supplementation?

NMN and NMNH may help with aging, energy, repair, and heart and brain health. But, more research is needed to understand their benefits.

What are the safety considerations and potential side effects associated with NMN and NMNH?

NMN is generally safe based on human studies, with few side effects. NMNH’s safety is less known, so caution is advised. NMN’s dosage is clearer, but NMNH’s is still being studied.

Sources
  • https://doublewoodsupplements.com/blogs/articles/nmn-vs-nmnh – NMN vs. NMN-H: What’s the Difference
  • https://omre.co/blogs/news/nmn-vs-nmnh?srsltid=AfmBOorun5YhO50XPmCumhW_zr3Tx0p91-BuNxvqu_6BjxcJpyMUAFgt – NMN vs NMNH: Key Differences, Benefits, and Which One Is Right for You
  • https://aidevi.com/article/nmnh-vs-nmn-is-nmnh-better-than-nmn.html – NMNH vs. NMN: Is NMNH Better Than NMN?
  • https://youthandearth.com/blogs/blog/ultimate-guide-nmn – The Complete Guide to NMN (Nicotinamide Mononucleotide)
  • https://omre.co/blogs/news/nmn-side-effects?srsltid=AfmBOorUOPLhKAUEasLlDwdN8EwPDHEuL1do9SkIJ2pi6O3ywgHO2xAX – NMN Side Effects: What You Need to Know Before Taking It
  • https://omre.co/blogs/news/nmn-weight-loss?srsltid=AfmBOorOixQ7m4Xc-wgDk5ohJJjgtlyDPwx7ac60D0qwEH5BT9cTyjb2 – Does NMN Help With Weight Loss? Here’s Everything You Need to Know
  • https://en.wikipedia.org/wiki/Dihydronicotinamide_mononucleotide – Dihydronicotinamide mononucleotide
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10240123/ – NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health
  • https://www.biorxiv.org/content/10.1101/2020.11.03.366427v2.full – Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Causes Reductive Stress, and Suppresses Glycolysis and Cell Growth
  • https://www.uthpeak.com/nmnh-vs-nmn – NMNH vs NMN Comparison | UthPeak™
  • https://omre.co/blogs/news/nmn-vs-nmnh?srsltid=AfmBOorlNOCPOQK2kG1AtrKqVAR3WcSUDrVbF75KMR06oo_4ICAWJdoW – NMN vs NMNH: Key Differences, Benefits, and Which One Is Right for You
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC8444956/ – Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging
  • https://www.truniagen.com/blogs/tru-niagen-labs/nicotinamide-riboside-vs-nmn-debunking-the-nmn-science?srsltid=AfmBOooOvBlulMYrLv03WuSiEmr7H-epyKZffM1zvSvSSVlFn5fiOSIT – Nicotinamide Riboside vs NMN: Debunking the Science | Tru Niagen®
  • https://www.nmn.com/precursors/nmn-vs-nr – NMN vs NR: The Differences Between These 2 NAD+ Precursors
  • https://www.hygieiabiotech.com/nmnh-vs-nmn/ – NMNH vs NMN: Comparing Two Key NAD+ Precursors
  • https://www.biorxiv.org/content/10.1101/2020.11.03.366427v4.full.pdf – Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis, TCA Cycle and Cell Growth
  • https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage – NMN (Nicotinamide Mononucleotide): Benefits, Side Effects, and Dosage
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10721522/ – The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
  • https://omre.co/blogs/news/nmn-vs-nmnh?srsltid=AfmBOoqgHwS5AmKiH5BN0zb1ENPSKettmf04ZIszS2vqMWDKs9JaW43M – NMN vs NMNH: Key Differences, Benefits, and Which One Is Right for You
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC7352172/ – Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
  • https://www.postoprecovery.com/why-nmn-is-the-ultimate-anti-aging-supplement/?srsltid=AfmBOopQ7PSKR8XwzwiNgL-GEBas_ESSv-TazD_A4cX-i7CyatTJnwc1 – Why NMNH Is The Ultimate Anti-aging Supplement – Barrett Recovery
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